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Frank Manion

Chief Informatics Officer, Comprehensive Cancer Center
Director, Cancer Center Informatics
(734) 764-2473


Frank Manion, MS, is Chief Informatics Officer at the University of Michigan Comprehensive Cancer Center, Director of Cancer Informatics. In this role he serves as the senior biomedical informatics strategist, and has responsibility for clinical informatics, bioinformatics, and administrative computing functions.

For 25 years prior to joining the University of Michigan, Mr. Manion was the Chief Technology Officer for the Fox Chase Cancer Center in Philadelphia where he developed the bioinformatics shared facility, and worked with teams developing institutional data warehouses, installed modern medical record systems, and developed the campus cyberinfrastructure. Mr. Manion has played an active role in the caBIG Strategic Planning and Architecture Workspaces, and was the Principal Investigator for the caBIG Security Program.

Current initiatives his team is working on include a major analysis of biobanking software needs for the Cancer Center, the development of a Cancer Center data warehouse and knowledge management platform, and preparation for installation of the Epic Beacon oncology platform. He is also co-leading an initiative to develop a translational research information architecture strategy for the University of Michigan Health System.


Schumacher FR, Schmit SL, Jiao S, Edlund CK, Wang H, Zhang B, Hsu L, Huang S-C, Fischer CP, Harju JF, Idos GE, Lejbkowicz F, Manion FJ, McDonnell K, McNeil CE, Melas M, Rennert HS, Shi W, Thomas DC, Van Den Berg DJ, Hutter CM, Aragaki AK, Butterbach K, Caan BJ, Carlson CS, Chanock SJ, Curtis KR, Fuchs CS, Gala M, Giocannucci EL, Gogarten SM, Hayes RB, Henderson B, Hunter DJ, Jackson RD, Kolonel LN, Kooperberg C, Kury S, LaCroix A, Laurie CC, Laurie CA, Lemire M, Levine D, Ma J, Makar KW, Qu C, Taverna D, Ulrich CM, Wu K, Kono S, West DW, Berndt SI, Bézieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Coetzee GA, Conti DV, Duggan D, Figueiredo JC, Fortini BK, Gallinger SJ, W Gauderman J, Giles G, Green R, Haile R, Harrison TA, Hoffmeister M, Hopper JL, Hudson TJ, Jacobs E, Iwasaki M, Jee SHa, Jenkins M, Jia W-H, Joshi A, Li L, Lindor NM, Matsuo K, Moreno V, Mukherjee B, Newcomb PA, Potter JD, Raskin L, Rennert G, Rosse S, Severi G, Schoen RE, Seminara D, Shu X-O, Slattery ML, Tsugane S, White E, Xiang Y-B, Zanke BW, Zheng W, Le Marchand L, et al. Genome-wide association study of colorectal cancer identifies six new susceptibility loci. Nat Commun 2015;6:7138. doi:10.1038/ncomms8138.
Manion FJ, He Y, Eisenhauer E, Lin Y, Karnovsky A, Harris MR. Towards a Common Semantic Representation of Informed Consent for Biobank Specimens. In: International Conference On Biomedical Ontology.Vol 1309. International Conference on Biomedical Ontology. CEUR Workshop Proceedings; 2014:61 - 63. Available at:
Wang H, Burnett T, Kono S, Haiman CA, Iwasaki M, Wilkens LR, Loo LWM, Van Den Berg D, Kolonel LN, Henderson BE, Keku TO, Sandler RS, Signorello LB, Blot WJ, Newcomb PA, Pande M, Amos CI, West DW, Bézieau S, Berndt SI, Zanke BW, Hsu L, Lindor NM, Haile RW, Hopper JL, Jenkins MA, Gallinger S, Casey G, Stenzel SL, Schumacher FR, Peters U, Gruber SB, Tsugane S, Stram DO, Le Marchand L. Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. Nat Commun 2014;5:4613. doi:10.1038/ncomms5613.
Zhang B, Jia W-H, Matsuda K, Kweon S-S, Matsuo K, Xiang Y-B, Shin A, Jee SHa, Kim D-H, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji B-T, Pan Z-Z, Takahashi A, Shin M-H, Matsuda F, Gao Y-T, Oh JHwan, Kim S, Ahn Y-O, Chan AT, Chang-Claude J, Slattery ML, Gruber SB, Schumacher FR, Stenzel SL, Casey G, Kim H-R, Jeong J-Y, Park JWon, Li H-L, Hosono S, Cho S-H, Kubo M, Shu X-O, Zeng Y-X, Zheng W. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. Nat Genet 2014;46(6):533-42. doi:10.1038/ng.2985.
Manion FJ, Harris MR, Buyuktur AG, Clark PM, An LC, Hanauer DA. Leveraging EHR data for outcomes and comparative effectiveness research in oncology. Curr Oncol Rep 2012;14(6):494-501. doi:10.1007/s11912-012-0272-6.
Hanauer DA, Liu Y, Mei Q, Manion FJ, Balis UJ, Zheng K. Hedging their mets: the use of uncertainty terms in clinical documents and its potential implications when sharing the documents with patients. AMIA Annu Symp Proc 2012;2012:321-30.
Zheng K, Mei Q, Yang L, Manion FJ, Balis UJ, Hanauer DA. Voice-dictated versus typed-in clinician notes: linguistic properties and the potential implications on natural language processing. AMIA Annu Symp Proc 2011;2011:1630-8.
Meropol NJ, Daly MB, Vig HS, Manion FJ, Manne SL, Mazar C, Murphy C, Solarino N, Zubarev V. Delivery of Internet-based cancer genetic counselling services to patients' homes: a feasibility study. J Telemed Telecare 2011;17(1):36-40. doi:10.1258/jtt.2010.100116.
Qian Y, Tchuvatkina O, Spidlen J, Wilkinson P, Gasparetto M, Jones AR, Manion FJ, Scheuermann RH, Sekaly R-P, Brinkman RR. FuGEFlow: data model and markup language for flow cytometry. BMC Bioinformatics 2009;10:184. doi:10.1186/1471-2105-10-184.
Manion FJ, Robbins RJ, Weems WA, Crowley RS. Security and privacy requirements for a multi-institutional cancer research data grid: an interview-based study. BMC Med Inform Decis Mak 2009;9:31. doi:10.1186/1472-6947-9-31.
Min H, Manion FJ, Goralczyk E, Wong Y-N, Ross E, J Beck R. Integration of prostate cancer clinical data using an ontology. J Biomed Inform 2009;42(6):1035-45. doi:10.1016/j.jbi.2009.05.007.
Bidaut G, Manion FJ, Garcia C, Ochs MF. WaveRead: automatic measurement of relative gene expression levels from microarrays using wavelet analysis. J Biomed Inform 2006;39(4):379-88. doi:10.1016/j.jbi.2005.10.001.
Grant JD, Somers LA, Zhang Y, Manion FJ, Bidaut G, Ochs MF. FGDP: functional genomics data pipeline for automated, multiple microarray data analyses. Bioinformatics 2004;20(2):282-3.
Kossenkov A, Manion FJ, Korotkov E, Moloshok TD, Ochs MF. ASAP: automated sequence annotation pipeline for web-based updating of sequence information with a local dynamic database. Bioinformatics 2003;19(5):675-6.
Grant JD, Dunbrack RL, Manion FJ, Ochs MF. BeoBLAST: distributed BLAST and PSI-BLAST on a Beowulf cluster. Bioinformatics 2002;18(5):765-6.
Moloshok TD, Klevecz RR, Grant JD, Manion FJ, Speier WF, Ochs MF. Application of Bayesian decomposition for analysing microarray data. Bioinformatics 2002;18(4):566-75.
Grant JD, Broccoli D, Muquit M, Manion FJ, Tisdall J, Ochs MF. Telometric: a tool providing simplified, reproducible measurements of telomeric DNA from constant field agarose gels. Biotechniques 2001;31(6):1314-6, 1318.
University of Michigan Comprehensive Cancer Center at North Campus Reserach Complex
1600 Huron Parkway, Bldg 100, Rm 100 
Mailing Address: 2800 Plymouth Rd, NCRC 100-1004
Ann Arbor, MI 48109-2800 
Ph. (734) 764-8848 Fax. (734) 615-0517
Please acknowledge the Cancer Center Support Grant (P30 CA046592) when publishing manuscripts or abstracts that utilized the services of the University of Michigan's Comprehensive Cancer Center's Shared Resource: Cancer Informatics.
Suggested language: "Research reported in this [publication/press release] was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA046592."

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