You are here

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.

TitleTrans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
Publication TypeJournal Article
Year of Publication2014
AuthorsWang, H, Burnett, T, Kono, S, Haiman, CA, Iwasaki, M, Wilkens, LR, Loo, LWM, Van Den Berg, D, Kolonel, LN, Henderson, BE, Keku, TO, Sandler, RS, Signorello, LB, Blot, WJ, Newcomb, PA, Pande, M, Amos, CI, West, DW, Bézieau, S, Berndt, SI, Zanke, BW, Hsu, L, Lindor, NM, Haile, RW, Hopper, JL, Jenkins, MA, Gallinger, S, Casey, G, Stenzel, SL, Schumacher, FR, Peters, U, Gruber, SB, Tsugane, S, Stram, DO, Le Marchand, L
Corporate Authors, ,
JournalNat Commun
Volume5
Pagination4613
Date Published2014
ISSN2041-1723
Abstract

The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.

DOI10.1038/ncomms5613
Alternate JournalNat Commun
PubMed ID25105248
PubMed Central IDPMC4180879
Grant List1R01-CA104132 / CA / NCI NIH HHS / United States
1R01-CA126895 / CA / NCI NIH HHS / United States
1R01-CA126895-S1 / CA / NCI NIH HHS / United States
2U24-CA074806 / CA / NCI NIH HHS / United States
CA 087969 / CA / NCI NIH HHS / United States
CA-95-011 / CA / NCI NIH HHS / United States
CA16672 / CA / NCI NIH HHS / United States
HHSN268201100001C / / PHS HHS / United States
HHSN268201100002C / / PHS HHS / United States
HHSN268201100003C / / PHS HHS / United States
HHSN268201100004C / / PHS HHS / United States
HHSN268201100046C / / PHS HHS / United States
HHSN271201100004C / / PHS HHS / United States
K05 CA154337 / CA / NCI NIH HHS / United States
K05 CA154337 / CA / NCI NIH HHS / United States
K07 CA160753 / CA / NCI NIH HHS / United States
K07CA160753 / CA / NCI NIH HHS / United States
P01 CA 055075 / CA / NCI NIH HHS / United States
P01 CA 087969 / CA / NCI NIH HHS / United States
P01 CA033619 / CA / NCI NIH HHS / United States
P01 CA033619 / CA / NCI NIH HHS / United States
P01 CA055075 / CA / NCI NIH HHS / United States
P01 CA087969 / CA / NCI NIH HHS / United States
P30 CA014089 / CA / NCI NIH HHS / United States
P30 CA014089 / CA / NCI NIH HHS / United States
P30 CA016672 / CA / NCI NIH HHS / United States
P50 CA 106991 / CA / NCI NIH HHS / United States
P50 CA 127003 / CA / NCI NIH HHS / United States
P50 CA106991 / CA / NCI NIH HHS / United States
P50 CA127003 / CA / NCI NIH HHS / United States
R01 137178 / / PHS HHS / United States
R01 CA 66635 / CA / NCI NIH HHS / United States
R01 CA042182 / CA / NCI NIH HHS / United States
R01 CA042182 / CA / NCI NIH HHS / United States
R01 CA048998 / CA / NCI NIH HHS / United States
R01 CA059045 / CA / NCI NIH HHS / United States
R01 CA059045 / CA / NCI NIH HHS / United States
R01 CA063464 / CA / NCI NIH HHS / United States
R01 CA066635 / CA / NCI NIH HHS / United States
R01 CA076366 / CA / NCI NIH HHS / United States
R01 CA076366 / CA / NCI NIH HHS / United States
R01 CA081488 / CA / NCI NIH HHS / United States
R01 CA092447 / CA / NCI NIH HHS / United States
R01 CA104132 / CA / NCI NIH HHS / United States
R01 CA126895 / CA / NCI NIH HHS / United States
R01 CA132839 / CA / NCI NIH HHS / United States
R01 CA137178 / CA / NCI NIH HHS / United States
R01 CA137178 / CA / NCI NIH HHS / United States
R01 CA48998 / CA / NCI NIH HHS / United States
R01 CA60987 / CA / NCI NIH HHS / United States
R01 CA63464 / CA / NCI NIH HHS / United States
R01 CA81488 / CA / NCI NIH HHS / United States
R01-CA1326792 / CA / NCI NIH HHS / United States
R01-CA132839 / CA / NCI NIH HHS / United States
R01CA092447 / CA / NCI NIH HHS / United States
R37 CA054281 / CA / NCI NIH HHS / United States
R37 CA54281 / CA / NCI NIH HHS / United States
RC2 CA148085 / CA / NCI NIH HHS / United States
RC2-CA148085 / CA / NCI NIH HHS / United States
T32 ES013678 / ES / NIEHS NIH HHS / United States
T32 ES013678 / ES / NIEHS NIH HHS / United States
T32 HG000040 / HG / NHGRI NIH HHS / United States
T32 HG000040 / HG / NHGRI NIH HHS / United States
U01 CA 093326 / CA / NCI NIH HHS / United States
U01 CA074783 / CA / NCI NIH HHS / United States
U01 CA074783 / CA / NCI NIH HHS / United States
U01 CA074794 / CA / NCI NIH HHS / United States
U01 CA074794 / CA / NCI NIH HHS / United States
U01 CA074799 / CA / NCI NIH HHS / United States
U01 CA074799 / CA / NCI NIH HHS / United States
U01 CA074800 / CA / NCI NIH HHS / United States
U01 CA074800 / CA / NCI NIH HHS / United States
U01 CA074806 / CA / NCI NIH HHS / United States
U01 CA093326 / CA / NCI NIH HHS / United States
U01 CA097735 / CA / NCI NIH HHS / United States
U01 CA097735 / CA / NCI NIH HHS / United States
U01 CA122839 / CA / NCI NIH HHS / United States
U01 CA137088 / CA / NCI NIH HHS / United States
U01 CA137088 / CA / NCI NIH HHS / United States
U01 HG 004438 / HG / NHGRI NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
U01 HG004446 / HG / NHGRI NIH HHS / United States
U01 HG004726 / HG / NHGRI NIH HHS / United States
U01-HG004726 / HG / NHGRI NIH HHS / United States
U01CA122839 / CA / NCI NIH HHS / United States
U19 CA148107 / CA / NCI NIH HHS / United States
U19 CA148107 / CA / NCI NIH HHS / United States
U24 CA074806 / CA / NCI NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
UM1 CA167552 / CA / NCI NIH HHS / United States
Z01 CP 010200 / CP / NCI NIH HHS / United States
/ / Canadian Institutes of Health Research / Canada
People: 
Frank Manion
University of Michigan Comprehensive Cancer Center at North Campus Reserach Complex
1600 Huron Parkway, Bldg 100, Rm 100 
Mailing Address: 2800 Plymouth Rd, NCRC 100-1004
Ann Arbor, MI 48109-2800 
Ph. (734) 764-8848 Fax. (734) 615-0517
Please acknowledge the Cancer Center Support Grant (P30 CA046592) when publishing manuscripts or abstracts that utilized the services of the University of Michigan's Comprehensive Cancer Center's Shared Resource: Cancer Informatics.
Suggested language: "Research reported in this [publication/press release] was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA046592."

Copyright © Cancer Center Informatics-2011 Regents of the University of Michigan