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Head and neck squamous cell carcinoma in pregnant women.

TitleHead and neck squamous cell carcinoma in pregnant women.
Publication TypeJournal Article
Year of Publication2013
AuthorsEliassen, AM, Hauff, SJ, Tang, AL, Thomas, DH, McHugh, JB, Walline, HM, Stoerker, J, Maxwell, JH, Worden, FP, Eisbruch, A, Czerwinski, MJ, Papagerakis, SM, Chepeha, DB, Bradford, CR, Hanauer, DA, Carey, TE, Prince, ME
JournalHead Neck
Volume35
Issue3
Pagination335-42
Date Published2013 Mar
ISSN1097-0347
KeywordsAdult, Carcinoma, Squamous Cell, Female, Head and Neck Neoplasms, Humans, Immunohistochemistry, Mass Spectrometry, Mouth Neoplasms, Multiplex Polymerase Chain Reaction, Papillomaviridae, Pregnancy, Pregnancy Complications, Neoplastic, Risk Factors, Tumor Markers, Biological
Abstract

BACKGROUND: The aim of this study was to investigate oral cancer in pregnant women, a rare but therapeutically challenging patient subset.METHODS: After institutional review board approval, an EMERSE search was used to identify all women treated at the University of Michigan from 1998 to 2010 with head and neck squamous cell carcinoma (HNSCC) during pregnancy. This identified 4 patients with tongue cancer. Biomarkers and human papillomavirus (HPV) were assessed by immunohistochemistry and multiplex PCR/mass spectrometry, respectively.RESULTS: Two patients responded well to therapy and are alive more than 10 years after diagnosis; 2 patients died of disease. All tumors overexpressed EGFR and Bcl-xL, 3 of 4 overexpressed c-Met, both tumors that progressed overexpressed p53. All tumors were negative for HPV, p16, estrogen receptor, progesterone receptor, and HER-2.CONCLUSIONS: Biomarkers of aggressive tumors (high EGFR, c-Met; high Bcl-xL-low p53) did not correlate with outcome. Additional studies are needed to determine whether perineural invasion, delay in diagnosis, and p53 overexpression are factors in poor survival.

DOI10.1002/hed.22973
Alternate JournalHead Neck
PubMed ID22422571
PubMed Central IDPMC3399935
Grant List1RR024986 / RR / NCRR NIH HHS / United States
P30 CA046592 / CA / NCI NIH HHS / United States
P30 CA046592-23 / CA / NCI NIH HHS / United States
P30 CA46592 / CA / NCI NIH HHS / United States
P30 DC005188 / DC / NIDCD NIH HHS / United States
P30 DC005188-09 / DC / NIDCD NIH HHS / United States
P30 DC05188 / DC / NIDCD NIH HHS / United States
P50 CA097248 / CA / NCI NIH HHS / United States
P50 CA097248-09 / CA / NCI NIH HHS / United States
P50 CA97248 / CA / NCI NIH HHS / United States
R01 DE019126 / DE / NIDCR NIH HHS / United States
R01 DE019126-04 / DE / NIDCR NIH HHS / United States
R01-DE019126 / DE / NIDCR NIH HHS / United States
T32 CA009676 / CA / NCI NIH HHS / United States
T32 DC005356 / DC / NIDCD NIH HHS / United States
T32 DC005356-04 / DC / NIDCD NIH HHS / United States
T32 DC05356 / DC / NIDCD NIH HHS / United States
T32-CA9676 / CA / NCI NIH HHS / United States
People: 
David Hanauer
University of Michigan Comprehensive Cancer Center at North Campus Reserach Complex
1600 Huron Parkway, Bldg 100, Rm 100 
Mailing Address: 2800 Plymouth Rd, NCRC 100-1004
Ann Arbor, MI 48109-2800 
Ph. (734) 764-8848 Fax. (734) 615-0517
Please acknowledge the Cancer Center Support Grant (P30 CA046592) when publishing manuscripts or abstracts that utilized the services of the University of Michigan's Comprehensive Cancer Center's Shared Resource: Cancer Informatics.
Suggested language: "Research reported in this [publication/press release] was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA046592."

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