Title | New perspectives on the biology of acute GVHD. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Paczesny, S, Hanauer, DA, Sun, Y, Reddy, P |
Journal | Bone Marrow Transplant |
Volume | 45 |
Issue | 1 |
Pagination | 1-11 |
Date Published | 2010 Jan |
ISSN | 1476-5365 |
Keywords | Animals, Antigen Presentation, Antigen-Presenting Cells, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Immunity, Innate, T-Lymphocyte Subsets, Transplantation, Homologous |
Abstract | The use of allogeneic hematopoietic cell transplantation (HCT) has increased as new techniques have been developed for transplantation in patients who previously would not have been considered HCT candidates. However, its efficacy continued to be limited by the development of frequent and severe acute GVHD. The complex and intricate pathophysiology of acute GVHD is a consequence of interactions between the donor and host innate and adaptive immune responses. Multiple inflammatory molecules and cell types are implicated in the development of GVHD that can be categorized as: (1) triggers that initiate GVHD by therapy-induced tissue damage and the antigen disparities between host and graft tissue; (2) sensors that detect the triggers, that is, process and present alloantigens; (3) mediators such as T-cell subsets (naive, memory, regulatory, Th17 and natural killer T cells) and (4) the effectors and amplifiers that cause damage of the target organs. These multiple inflammatory molecules and cell types that are implicated in the development of GVHD have been described with models that use stepwise cascades. Herein, we provide a novel perspective on the immunobiology of acute GVHD and briefly discuss some of the outstanding questions and limitations of the model systems. |
DOI | 10.1038/bmt.2009.328 |
Alternate Journal | Bone Marrow Transplant. |
PubMed ID | 19946340 |
Grant List | AI-075284 / AI / NIAID NIH HHS / United States HL-090775 / HL / NHLBI NIH HHS / United States |
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592. The content is solely the responsibility
of the authors and does not necessarily represent the official views of the
National Institutes of Health.
Research reported in this publication was supported by the National Cancer Institutes of
Health under Award Number P30CA046592 by the use of the following Cancer Center
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