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Bioinformatics approaches in the study of cancer.

TitleBioinformatics approaches in the study of cancer.
Publication TypeJournal Article
Year of Publication2007
AuthorsHanauer, DA, Rhodes, DR, Sinha-Kumar, C, Chinnaiyan, AM
JournalCurr Mol Med
Volume7
Issue1
Pagination133-41
Date Published2007 Feb
ISSN1566-5240
KeywordsAnimals, Biological Markers, Computational Biology, Databases, Genetic, Humans, Neoplasms, Oligonucleotide Array Sequence Analysis
Abstract

A revolution is underway in the approach to studying the genetic basis of cancer. Massive amounts of data are now being generated via high-throughput techniques such as DNA microarray technology and new computational algorithms have been developed to aid in analysis. At the same time, standards-based repositories, including the Stanford Microarray Database and the Gene Expression Omnibus have been developed to store and disseminate the results of microarray experiments. Bioinformatics, the convergence of biology, information science, and computation, has played a key role in these developments. Recently developed techniques include Module Maps, SLAMS (Stepwise Linkage Analysis of Microarray Signatures), and COPA (Cancer Outlier Profile Analysis). What these techniques have in common is the application of novel algorithms to find high-level gene expression patterns across heterogeneous microarray experiments. Large-scale initiatives are underway as well. The Cancer Genome Atlas (TCGA) project is a logical extension of the Human Genome Project and is meant to produce a comprehensive atlas of genetic changes associated with cancer. The Cancer Biomedical Informatics Grid (caBIG), led by the NCI, also represents a colossal initiative involving virtually all aspects of cancer research and may help to transform the way cancer research is conducted and data are shared.

Alternate JournalCurr. Mol. Med.
PubMed ID17311538
Grant List5 P30 CA46592 / CA / NCI NIH HHS / United States
People: 
David Hanauer
University of Michigan Comprehensive Cancer Center at North Campus Reserach Complex
1600 Huron Parkway, Bldg 100, Rm 100 
Mailing Address: 2800 Plymouth Rd, NCRC 100-1004
Ann Arbor, MI 48109-2800 
Ph. (734) 764-8848 Fax. (734) 615-0517
Please acknowledge the Cancer Center Support Grant (P30 CA046592) when publishing manuscripts or abstracts that utilized the services of the University of Michigan's Comprehensive Cancer Center's Shared Resource: Cancer Informatics.
Suggested language: "Research reported in this [publication/press release] was supported by the National Cancer Institute of the National Institutes of Health under award number P30CA046592."

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